NPLEX 2 is an integrated case-based examination that covers the topics of physical and clinical diagnosis, lab tests and imaging, botanical medicine, homeopathy, nutrition, physical medicine, health psychology, emergency medicine, medical procedures, public health, pharmacology, and research. It is designed to test the skills and knowledge that an entry-level physician must have in order to practice safely. The largest challenge with this exam is managing the volume of information, which essentially condenses 4 years of education into one examination. We will highlight our top recommendations, which will apply to most students. This list has been updated for the 2018 NPLEX 2 exam sittings.